CUX2

Gene Information

Official Symbol: CUX2
Official Name: cut like homeobox 2
Aliases and Previous Symbols: N/A
Entrez ID: 23316
UniProt: O14529
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013].
UniProt Summary: May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3437
Expression level (log2 read counts): -1.95

Expression Distribution

CUT
Homeobox

short-term memory
positive regulation of dendritic spine morphogenesis
positive regulation of excitatory postsynaptic potential
positive regulation of dendrite morphogenesis
modulation of excitatory postsynaptic potential
positive regulation of dendritic spine development
regulation of dendritic spine morphogenesis
positive regulation of nervous system process
positive regulation of synapse assembly
positive regulation of dendrite development
regulation of dendritic spine development
regulation of dendrite morphogenesis
regulation of postsynapse organization
regulation of synapse assembly
memory
regulation of nervous system process
regulation of dendrite development
positive regulation of synaptic transmission
positive regulation of cell morphogenesis involved in differentiation
regulation of synapse organization
regulation of synapse structure or activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
learning or memory
positive regulation of neuron projection development
cognition
regulation of cell morphogenesis involved in differentiation
RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of neuron differentiation
Golgi vesicle transport
positive regulation of cell projection organization
sequence-specific DNA binding
regulation of membrane potential
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of cellular component biogenesis
positive regulation of nervous system development