CXCR4

Gene Information

Official Symbol: CXCR4
Official Name: C-X-C motif chemokine receptor 4
Aliases and Previous Symbols: N/A
Entrez ID: 7852
UniProt: P61073
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:17197449, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:20228059, ECO:0000269|PubMed:20505072, ECO:0000269|PubMed:8752280, ECO:0000269|PubMed:8752281}. (Microbial infection) Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. {ECO:0000269|PubMed:11276205}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-3.25
Tunicamycin 0.04μM R07 exp418	-2.87
Bortezomib 0.005μM R00 exp6	-2.62
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.42
Citral 75μM R06 exp275	-1.95
Taxol 0.002μM R01 exp54	-1.77
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	2.11

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15335
Expression level (log2 read counts): 9.24

Expression Distribution

7TM GPCR Srsx
CXCR4 N
7tm 1

C-X-C motif chemokine 12 receptor activity
CXCL12-activated CXCR4 signaling pathway
C-X-C chemokine receptor CXCR4 signaling pathway
positive regulation of macrophage migration inhibitory factor signaling pathway
response to ultrasound
positive regulation of mesenchymal stem cell migration
regulation of mesenchymal stem cell migration
regulation of macrophage migration inhibitory factor signaling pathway
chemokine (C-X-C motif) ligand 12 signaling pathway
positive regulation of vascular wound healing
regulation of vascular wound healing
myosin light chain binding
C-X-C chemokine receptor activity
multi-organism membrane fusion
membrane fusion involved in viral entry into host cell
fusion of virus membrane with host plasma membrane
multi-organism membrane organization
endothelial tube morphogenesis
morphogenesis of an endothelium
detection of mechanical stimulus involved in sensory perception of pain
myelin maintenance
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus involved in sensory perception of pain
dendritic cell chemotaxis
detection of temperature stimulus
sensory perception of temperature stimulus
dendritic cell migration
multi-organism cellular process
positive regulation of dendrite extension
C-C chemokine receptor activity
positive regulation of oligodendrocyte differentiation
chemokine binding
C-C chemokine binding
regulation of dendrite extension
detection of mechanical stimulus involved in sensory perception
response to morphine
response to isoquinoline alkaloid
coreceptor activity
regulation of oligodendrocyte differentiation
cell leading edge