CYBB

Gene Information

Official Symbol: CYBB
Official Name: cytochrome b-245 beta chain
Aliases and Previous Symbols: N/A
Entrez ID: 1536
UniProt: P04839
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008].
UniProt Summary: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15145
Expression level (log2 read counts): -1.72

Expression Distribution

Screen	Score
QNZ 0.01μM R08 exp439	-1.94
UMK57 1μM R01 exp59	1.75
Taxol 0.002μM R01 exp54	2

FAD binding 8
NAD binding 6
FAD binding 6
Ferric reduct

cellular response to L-glutamine
response to L-glutamine
hypoxia-inducible factor-1alpha signaling pathway
response to aldosterone
hydrogen peroxide biosynthetic process
superoxide-generating NADPH oxidase activity
antibiotic biosynthetic process
cellular response to ethanol
NADPH oxidase complex
superoxide anion generation
perinuclear endoplasmic reticulum
respiratory burst
positive regulation of tumor necrosis factor biosynthetic process
reactive oxygen species biosynthetic process
response to angiotensin
regulation of tumor necrosis factor biosynthetic process
response to mineralocorticoid
hydrogen peroxide metabolic process
cellular response to cadmium ion
superoxide metabolic process
voltage-gated ion channel activity
flavin adenine dinucleotide binding
rough endoplasmic reticulum
response to cadmium ion
vascular endothelial growth factor receptor signaling pathway
cellular response to nutrient
positive regulation of cytokine biosynthetic process
cellular response to amino acid stimulus
tertiary granule membrane
phagocytic vesicle membrane
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
cell redox homeostasis
electron transfer activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
cellular response to alcohol
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
specific granule membrane
antigen processing and presentation of peptide antigen via MHC class I
antibiotic metabolic process