CYC1

Gene Information

Official Symbol: CYC1
Official Name: cytochrome c1
Aliases and Previous Symbols: N/A
Entrez ID: 1537
UniProt: P08574
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013].
UniProt Summary: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 212/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	9/28
blood	6/28
bone	4/26
breast	14/33
central nervous system	5/56
cervix	1/4
colorectal	9/17
esophagus	4/13
fibroblast	0/1
gastric	7/16
kidney	5/21
liver	9/20
lung	22/75
lymphocyte	6/16
ovary	3/26
pancreas	5/24
peripheral nervous system	3/16
plasma cell	5/15
prostate	0/1
skin	10/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	5/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 356
Expression level (log2 read counts): 6.59

Expression Distribution

Screen	Score
Hydroxyurea 100μM R07 exp329	1.71
Ammonium tetrathiomolybdate 10μM R08 exp448	1.89
Phenformin 20μM R03 exp143	2.03

electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
mitochondrial respiratory chain complex III
mitochondrial electron transport, ubiquinol to cytochrome c
mitochondrial ATP synthesis coupled proton transport
ATP synthesis coupled proton transport
energy coupled proton transport, down electrochemical gradient
ATP biosynthetic process
response to glucagon
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
nucleoside triphosphate metabolic process
mitochondrial transmembrane transport
respiratory electron transport chain
oxidative phosphorylation
heme binding
proton transmembrane transport
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
cellular respiration
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
electron transport chain
ATP metabolic process
mitochondrial transport
energy derivation by oxidation of organic compounds
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process