CYP11A1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones. {ECO:0000269|PubMed:21636783}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Thimerosal 0.85μM R08 exp529	1.72
S-trityl-L-cysteine 0.5μM R05 exp243	1.85

cholesterol monooxygenase (side-chain-cleaving) activity
cortisol metabolic process
glucocorticoid biosynthetic process
tertiary alcohol metabolic process
vitamin D metabolic process
C21-steroid hormone biosynthetic process
glucocorticoid metabolic process
C21-steroid hormone metabolic process
fat-soluble vitamin metabolic process
steroid hormone biosynthetic process
hormone biosynthetic process
cellular ketone metabolic process
primary alcohol metabolic process
cholesterol metabolic process
cellular hormone metabolic process
vitamin metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
iron ion binding
sterol metabolic process
heme binding
hormone metabolic process
steroid metabolic process
cellular response to peptide hormone stimulus
alcohol metabolic process
cellular response to peptide
mitochondrial matrix
response to peptide hormone
mitochondrial inner membrane
organic hydroxy compound metabolic process
response to peptide
drug metabolic process
regulation of hormone levels
lipid biosynthetic process
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound
response to hormone
oxidation-reduction process
response to organonitrogen compound