DACT1

Gene Information

Official Symbol: DACT1
Official Name: dishevelled binding antagonist of beta catenin 1
Aliases and Previous Symbols: N/A
Entrez ID: 51339
UniProt: Q9NYF0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
UniProt Summary: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome- dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. {ECO:0000250, ECO:0000269|PubMed:15580286, ECO:0000269|PubMed:16446366, ECO:0000269|PubMed:17197390, ECO:0000269|PubMed:18936100, ECO:0000269|PubMed:22470507}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18923
Expression level (log2 read counts): 2.52

Expression Distribution

regulation of beta-catenin-TCF complex assembly
negative regulation of beta-catenin-TCF complex assembly
embryonic hindgut morphogenesis
hindgut morphogenesis
delta-catenin binding
hindgut development
regulation of nodal signaling pathway
beta-catenin destruction complex
regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of non-canonical Wnt signaling pathway
regulation of activin receptor signaling pathway
protein kinase A binding
negative regulation of JNK cascade
negative regulation of stress-activated MAPK cascade
negative regulation of stress-activated protein kinase signaling cascade
digestive tract morphogenesis
protein kinase C binding
RNA polymerase II transcription factor binding
beta-catenin binding
positive regulation of protein binding
negative regulation of protein binding
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
regulation of establishment of planar polarity
histone deacetylase binding
digestive tract development
negative regulation of protein complex assembly
positive regulation of cellular protein catabolic process
digestive system development
positive regulation of canonical Wnt signaling pathway
regulation of G1/S transition of mitotic cell cycle
neural tube development
regulation of cell cycle G1/S phase transition
negative regulation of MAPK cascade
negative regulation of binding
negative regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
positive regulation of binding
regulation of morphogenesis of an epithelium
regulation of JNK cascade