DBX1

Entrez Summary: N/A
UniProt Summary: Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

cell fate specification involved in pattern specification
ventral spinal cord interneuron specification
ventral spinal cord interneuron fate commitment
cell fate commitment involved in pattern specification
ventral spinal cord interneuron differentiation
spinal cord dorsal/ventral patterning
spinal cord patterning
neuron fate specification
ventral spinal cord development
cell differentiation in spinal cord
neuron fate commitment
dorsal/ventral pattern formation
cell fate specification
spinal cord development
central nervous system neuron differentiation
cell fate commitment
regionalization
sequence-specific DNA binding
pattern specification process
central nervous system development
neuron differentiation
generation of neurons
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis