DCLRE1A

Entrez Summary: N/A
UniProt Summary: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. {ECO:0000269|PubMed:15542852}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DRMBL
Lactamase B 2

5-3 exodeoxyribonuclease activity
protection from non-homologous end joining at telomere
telomere maintenance in response to DNA damage
telomere capping
interstrand cross-link repair
damaged DNA binding
double-strand break repair via nonhomologous end joining
non-recombinational repair
telomere maintenance
telomere organization
nuclear chromosome, telomeric region
fibrillar center
double-strand break repair
nucleic acid phosphodiester bond hydrolysis
anatomical structure homeostasis
cell division
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
chromosome organization
cell cycle
homeostatic process
cellular response to stress