DDX19A

Entrez Summary: N/A
UniProt Summary: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 62/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	7/26
breast	5/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	2/13
fibroblast	1/1
gastric	0/16
kidney	3/21
liver	1/20
lung	2/75
lymphocyte	1/16
ovary	2/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	1/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/29
uterus	0/5

Expression Distribution

Gene	Correlation
NXT1	0.466
HARS	0.45

DEAD
Helicase C

poly(A)+ mRNA export from nucleus
RNA helicase activity
cytoplasmic stress granule
nuclear pore
mRNA export from nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
protein export from nucleus
mRNA transport
nuclear export
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
nuclear membrane
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
molecular function
intracellular protein transport
RNA binding
ATP binding
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
membrane
gene expression