DDX60

Entrez Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017].
UniProt Summary: Positively regulates DDX58/RIG-I- and IFIH1/MDA5- dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:21791617}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Fluorouracil 20μM R00 exp2	-1.9
NFN1 0.1μM R01 exp49	-1.89
YM155 0.0002μM R01 exp61	-1.84
All-trans-Retinoic-Acid 40μM R07 exp334	1.75
PNU96415E 10μM R03 exp145	1.84

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of MDA-5 signaling pathway
regulation of MDA-5 signaling pathway
positive regulation of RIG-I signaling pathway
regulation of RIG-I signaling pathway
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
intermediate filament cytoskeleton
single-stranded RNA binding
RNA helicase activity
double-stranded RNA binding
regulation of defense response to virus
double-stranded DNA binding
defense response to virus
positive regulation of immune effector process
response to virus
positive regulation of innate immune response
positive regulation of response to biotic stimulus
positive regulation of cytokine production
regulation of innate immune response
regulation of immune effector process
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
regulation of cytokine production
regulation of defense response
innate immune response
regulation of multi-organism process
positive regulation of immune response
defense response to other organism
positive regulation of intracellular signal transduction
immune effector process
regulation of response to external stimulus
positive regulation of immune system process
regulation of immune response
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
regulation of response to stress
ATP binding