DEPTOR

Gene Information

Official Symbol: DEPTOR
Official Name: DEP domain containing MTOR interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 64798
UniProt: Q8TB45
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. {ECO:0000269|PubMed:19446321}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 0.07μM R08 exp431	-2.13
HMS-I1 1μM R01 exp46	-1.97
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.88
Nicotinamide 2000μM R01 exp50	-1.77
Golgicide-A 2μM R03 exp121	1.78

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8154
Expression level (log2 read counts): -0.51

Expression Distribution

negative regulation of cell size
negative regulation of TOR signaling
intracellular
regulation of TOR signaling
regulation of extrinsic apoptotic signaling pathway
regulation of cell size
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
regulation of cellular component size
regulation of apoptotic signaling pathway
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of anatomical structure size
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation
negative regulation of response to stimulus
regulation of cell death
intracellular signal transduction
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of intracellular signal transduction
regulation of protein modification process