DFFB

Entrez Summary: N/A
UniProt Summary: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DFF40
CIDE-N

apoptotic chromosome condensation
deoxyribonuclease activity
apoptotic DNA fragmentation
DNA catabolic process, endonucleolytic
apoptotic nuclear changes
cellular component disassembly involved in execution phase of apoptosis
DNA catabolic process
disordered domain specific binding
chromosome condensation
execution phase of apoptosis
DNA packaging
nuclear chromatin
protein domain specific binding
DNA conformation change
nucleic acid phosphodiester bond hydrolysis
protein homooligomerization
enzyme binding
nucleobase-containing compound catabolic process
cellular component disassembly
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
protein complex oligomerization
DNA metabolic process
nucleolus
cellular macromolecule catabolic process
apoptotic process
macromolecule catabolic process
programmed cell death
chromosome organization
identical protein binding
cell death
protein-containing complex assembly
organic substance catabolic process
cellular catabolic process
protein-containing complex subunit organization