DGKI
Gene Information
- Official Symbol: DGKI
- Official Name: diacylglycerol kinase iota
- Aliases and Previous Symbols: N/A
- Entrez ID: 9162
- UniProt: O75912
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ank 2 |
| DAGK cat |
| C1 1 |
| DAGK acc |
GO Terms
| extrinsic component of presynaptic active zone membrane |
| habituation |
| extrinsic component of postsynaptic density membrane |
| nonassociative learning |
| guanyl-nucleotide exchange factor complex |
| diacylglycerol kinase activity |
| Ras GTPase binding |
| regulation of long-term synaptic depression |
| GTPase inhibitor activity |
| NAD+ kinase activity |
| diacylglycerol metabolic process |
| protein kinase C-activating G protein-coupled receptor signaling pathway |
| excitatory synapse |
| negative regulation of GTPase activity |
| axon terminus |
| excitatory postsynaptic potential |
| positive regulation of Ras protein signal transduction |
| lipid phosphorylation |
| chemical synaptic transmission, postsynaptic |
| regulation of synaptic transmission, glutamatergic |
| positive regulation of small GTPase mediated signal transduction |
| regulation of synaptic vesicle exocytosis |
| Schaffer collateral - CA1 synapse |
| acylglycerol metabolic process |
| regulation of postsynaptic membrane potential |
| neutral lipid metabolic process |
| neurotransmitter secretion |
| signal release from synapse |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| synaptic vesicle |
| platelet activation |
| regulation of neurotransmitter transport |
| learning |
| dendritic spine |
| regulation of regulated secretory pathway |
| signal release |
| neurotransmitter transport |
| regulation of synaptic plasticity |
| lipid modification |
| regulation of exocytosis |
| regulation of Ras protein signal transduction |
| learning or memory |
| synapse |
| blood coagulation |
| coagulation |
| hemostasis |
| cognition |
| regulation of small GTPase mediated signal transduction |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| neuronal cell body |
| glycerolipid metabolic process |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| negative regulation of hydrolase activity |
| synaptic signaling |
| wound healing |
| regulation of GTPase activity |
| regulation of body fluid levels |
| regulation of vesicle-mediated transport |
| response to wounding |
| behavior |
| protein-containing complex |
| perinuclear region of cytoplasm |
| regulation of secretion by cell |
| negative regulation of catalytic activity |
| regulation of secretion |
| regulation of cellular localization |
| cellular lipid metabolic process |
| secretion by cell |
| positive regulation of intracellular signal transduction |
| export from cell |
| cell activation |
| cell-cell signaling |
| secretion |
| negative regulation of molecular function |
| lipid metabolic process |
| regulation of hydrolase activity |
| phosphorylation |
| G protein-coupled receptor signaling pathway |
| nervous system process |
| ATP binding |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dexamethasone 0.006μM R07 exp351 | -1.81 |
| 2-Deoxy-D-glucose 800μM R05 exp214 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10858
- Expression level (log2 read counts): -1.37
Expression Distribution
DGKI Expression in NALM6 Cells: -1.37
