DHCR24

Entrez Summary: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:22010141}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

delta24(24-1) sterol reductase activity
delta24-sterol reductase activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
plasminogen activation
amyloid precursor protein catabolic process
amyloid precursor protein metabolic process
male genitalia development
peptide antigen binding
FAD binding
zymogen activation
cholesterol biosynthetic process
secondary alcohol biosynthetic process
genitalia development
sterol biosynthetic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
alcohol biosynthetic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
cell cycle arrest
male sex differentiation
protein processing
organic hydroxy compound biosynthetic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein maturation
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
Ras protein signal transduction
negative regulation of peptidase activity
steroid metabolic process
sex differentiation
regulation of neuron death
alcohol metabolic process
small GTPase mediated signal transduction
enzyme binding
negative regulation of proteolysis