DNAH2

Entrez Summary: N/A
UniProt Summary: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CCCP 0.1μM R00 exp10	-1.78
Bafilomycin-A1 0.009μM R08 exp454	-1.77

axonemal dynein complex
ATP-dependent microtubule motor activity, minus-end-directed
dynein complex
dynein light chain binding
dynein intermediate chain binding
dynein light intermediate chain binding
microtubule motor activity
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
motile cilium
axoneme
microtubule-based movement
microtubule
microtubule-based process
localization of cell
cell motility
locomotion
ATP binding
movement of cell or subcellular component