DNAJA2

Entrez Summary: N/A
UniProt Summary: Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R08 exp439	-2.1
Lead acetate 2000μM R08 exp497	-2.08
CyclicAMP 200μM R08 exp475	-1.95
TNF-alpha 44ng/ml R08 exp533	-1.79
Sulforaphane 9μM R08 exp526 no dilution day6	-1.78
Cyclosporin-A 0.8μM R07 exp347	-1.71
INK128 0.2μM R02 exp70	-1.7
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.8
iCRT14 30μM R08 exp492	1.81
UM0129480 7μM R02 exp85	2.15
Oligomycin-A 2μM R00 exp25	2.45

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ATPase activator activity
protein refolding
positive regulation of ATPase activity
heat shock protein binding
regulation of ATPase activity
chaperone binding
response to heat
unfolded protein binding
response to temperature stimulus
protein folding
positive regulation of hydrolase activity
positive regulation of cell population proliferation
response to abiotic stimulus
regulation of hydrolase activity
positive regulation of catalytic activity
ATP binding
regulation of cell population proliferation
positive regulation of molecular function
membrane