DNAJB1

Entrez Summary: N/A
UniProt Summary: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DnaJ C
DnaJ

sperm head
negative regulation of inclusion body assembly
negative regulation of transcription from RNA polymerase II promoter in response to stress
regulation of inclusion body assembly
ATPase activator activity
chaperone cofactor-dependent protein refolding
de novo posttranslational protein folding
de novo protein folding
Hsp70 protein binding
positive regulation of ATPase activity
chaperone-mediated protein folding
regulation of cellular response to heat
ATPase binding
regulation of ATPase activity
chaperone binding
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
unfolded protein binding
dendritic spine
response to unfolded protein
response to topologically incorrect protein
protein folding
transcription corepressor activity
postsynaptic density
cadherin binding
glutamatergic synapse
neuronal cell body
forebrain development
negative regulation of cellular component organization
regulation of cellular response to stress
brain development
positive regulation of hydrolase activity
head development
nucleolus
negative regulation of transcription by RNA polymerase II
regulation of cellular component biogenesis
central nervous system development
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process