DPM2

Entrez Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity. {ECO:0000269|PubMed:10944123}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 41/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	2/21
liver	2/20
lung	4/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	10/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	0/29
uterus	1/5

Expression Distribution

Screen	Score
Alda-1 10μM R06 exp262	-1.97
WNT3A 44ng/ml R08 exp537	1.7

dolichol-phosphate-mannose synthase complex
dolichyl-phosphate beta-D-mannosyltransferase activity
dolichol metabolic process
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
polyprenol metabolic process
enzyme regulator activity
preassembly of GPI anchor in ER membrane
protein O-linked mannosylation
protein mannosylation
GPI anchor biosynthetic process
GPI anchor metabolic process
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
mannosylation
glycolipid biosynthetic process
protein N-linked glycosylation
protein lipidation
lipoprotein biosynthetic process
integral component of endoplasmic reticulum membrane
glycolipid metabolic process
phosphatidylinositol biosynthetic process
liposaccharide metabolic process
protein O-linked glycosylation
lipoprotein metabolic process
membrane lipid biosynthetic process
isoprenoid metabolic process
phosphatidylinositol metabolic process
membrane lipid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
protein glycosylation
macromolecule glycosylation
glycosylation
regulation of protein stability
glycerophospholipid metabolic process
alcohol metabolic process
glycoprotein biosynthetic process
phospholipid metabolic process
glycerolipid metabolic process