DSG1

Entrez Summary: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015].
UniProt Summary: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cadherin
Cadherin C

toxic substance binding
gamma-catenin binding
desmosome
response to progesterone
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cytoplasmic side of plasma membrane
lateral plasma membrane
ficolin-1-rich granule membrane
maternal process involved in female pregnancy
cornified envelope
cell-cell junction assembly
cornification
cell-cell junction organization
cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
cell-cell junction
protein stabilization
female pregnancy
response to ketone
multi-multicellular organism process
cell junction organization
keratinization
cell-cell adhesion via plasma-membrane adhesion molecules
keratinocyte differentiation
regulation of protein stability
epidermal cell differentiation
apical plasma membrane
response to steroid hormone
skin development
epidermis development
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
cell-cell adhesion
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation