DSG4

Entrez Summary: This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016].
UniProt Summary: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cadherin C
Cadherin

desmosome
cornified envelope
hair follicle development
skin epidermis development
molting cycle process
hair cycle process
BMP signaling pathway
hair cycle
molting cycle
cellular response to BMP stimulus
response to BMP
cornification
homophilic cell adhesion via plasma membrane adhesion molecules
cell-cell junction
transmembrane receptor protein serine/threonine kinase signaling pathway
keratinization
cell-cell adhesion via plasma-membrane adhesion molecules
keratinocyte differentiation
epidermal cell differentiation
skin development
epidermis development
cellular response to growth factor stimulus
cell-cell adhesion
response to growth factor
epithelial cell differentiation
enzyme linked receptor protein signaling pathway
calcium ion binding
cell adhesion
biological adhesion
programmed cell death
cell death
epithelium development
cellular response to endogenous stimulus
response to endogenous stimulus
tissue development