DSTN

Entrez Summary: N/A
UniProt Summary: Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner. {ECO:0000269|PubMed:11812157}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
THZ531 0.225μM R08 exp444	-1.89
Quercetin 20μM R08 exp517	-1.76

actin filament fragmentation
actin filament severing
actin filament depolymerization
positive regulation of actin filament depolymerization
positive regulation of protein depolymerization
protein depolymerization
positive regulation of protein complex disassembly
actin polymerization or depolymerization
regulation of actin filament depolymerization
cortical actin cytoskeleton
regulation of protein depolymerization
regulation of protein complex disassembly
cellular protein complex disassembly
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
actin filament binding
actin cytoskeleton
positive regulation of cytoskeleton organization
protein-containing complex disassembly
actin filament organization
regulation of actin filament organization
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of cellular component size
regulation of actin filament-based process
cellular component disassembly
supramolecular fiber organization
actin cytoskeleton organization
regulation of anatomical structure size
regulation of cytoskeleton organization
actin filament-based process
positive regulation of organelle organization
cytoskeleton organization
positive regulation of cellular component organization
regulation of organelle organization
protein-containing complex subunit organization