DSTYK

Gene Information

Official Symbol: DSTYK
Official Name: dual serine/threonine and tyrosine protein kinase
Aliases and Previous Symbols: N/A
Entrez ID: 25778
UniProt: Q6XUX3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14267
Expression level (log2 read counts): 4.96

Expression Distribution

Screen	Score
VER-155008 3.9μM R06 exp301	-1.76
Salubrinal 20μM R07 exp399	-1.71
LJH685 5μM R02 exp73	1.87

Pkinase
Pkinase Tyr

positive regulation of fibroblast growth factor receptor signaling pathway
regulation of fibroblast growth factor receptor signaling pathway
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
basolateral plasma membrane
positive regulation of ERK1 and ERK2 cascade
regulation of cellular response to growth factor stimulus
regulation of ERK1 and ERK2 cascade
apical plasma membrane
protein serine/threonine kinase activity
cellular response to growth factor stimulus
response to growth factor
positive regulation of MAPK cascade
cell junction
positive regulation of kinase activity
positive regulation of transferase activity
regulation of MAPK cascade
regulation of kinase activity
peptidyl-amino acid modification
negative regulation of apoptotic process
negative regulation of programmed cell death
protein phosphorylation
regulation of transferase activity
negative regulation of cell death
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
cellular response to endogenous stimulus
positive regulation of protein modification process
phosphorylation
positive regulation of catalytic activity
regulation of protein phosphorylation
response to endogenous stimulus
ATP binding