DUOXA2

Entrez Summary: This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5.[provided by RefSeq, Feb 2010].
UniProt Summary: Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis. {ECO:0000269|PubMed:16651268}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of hydrogen peroxide biosynthetic process
regulation of thyroid hormone generation
positive regulation of hydrogen peroxide metabolic process
positive regulation of cofactor metabolic process
regulation of hydrogen peroxide biosynthetic process
regulation of hydrogen peroxide metabolic process
regulation of cofactor metabolic process
hydrogen peroxide metabolic process
regulation of hormone metabolic process
cell leading edge
positive regulation of reactive oxygen species biosynthetic process
apical part of cell
regulation of reactive oxygen species biosynthetic process
positive regulation of reactive oxygen species metabolic process
antibiotic metabolic process
reactive oxygen species metabolic process
regulation of reactive oxygen species metabolic process
protein maturation
regulation of inflammatory response
enzyme binding
cofactor metabolic process
drug metabolic process
positive regulation of cell motility
regulation of hormone levels
positive regulation of cellular component movement
positive regulation of locomotion
regulation of defense response
regulation of cell motility
endoplasmic reticulum membrane
regulation of locomotion
regulation of cellular component movement
endoplasmic reticulum
regulation of response to external stimulus
regulation of response to stress
protein transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization