DVL3

Entrez Summary: This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

non-canonical Wnt signaling pathway via JNK cascade
non-canonical Wnt signaling pathway via MAPK cascade
positive regulation of neuron projection arborization
regulation of neuron projection arborization
planar cell polarity pathway involved in neural tube closure
regulation of establishment of planar polarity involved in neural tube closure
regulation of epithelial tube formation
beta-catenin destruction complex disassembly
frizzled binding
Rac GTPase binding
positive regulation of JUN kinase activity
beta-catenin binding
regulation of JUN kinase activity
canonical Wnt signaling pathway
neural tube closure
tube closure
Wnt signaling pathway, planar cell polarity pathway
primary neural tube formation
protease binding
neural tube formation
regulation of establishment of planar polarity
embryonic epithelial tube formation
regulation of embryonic development
epithelial tube formation
non-canonical Wnt signaling pathway
positive regulation of JNK cascade
morphogenesis of embryonic epithelium
tube formation
neural tube development
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
negative regulation of canonical Wnt signaling pathway
protein stabilization
regulation of morphogenesis of an epithelium
regulation of JNK cascade
negative regulation of Wnt signaling pathway
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
nuclear chromatin
protein-containing complex disassembly