DYNC1LI2

Entrez Summary: N/A
UniProt Summary: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dynein heavy chain binding
cytoplasmic dynein complex
centrosome localization
microtubule organizing center localization
cellular response to nerve growth factor stimulus
response to nerve growth factor
microtubule motor activity
kinetochore
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
late endosome
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
lysosome
microtubule-based movement
microtubule
protein homooligomerization
Golgi vesicle transport
microtubule cytoskeleton organization
centrosome
cellular response to growth factor stimulus
protein complex oligomerization
response to growth factor
organelle localization
microtubule-based process
cytoskeleton organization
cellular response to endogenous stimulus
response to endogenous stimulus
ATP binding
intracellular transport
movement of cell or subcellular component
protein-containing complex assembly
establishment of localization in cell
protein-containing complex subunit organization
vesicle-mediated transport
membrane