E2F7

Gene Information

Official Symbol: E2F7
Official Name: E2F transcription factor 7
Aliases and Previous Symbols: N/A
Entrez ID: 144455
UniProt: Q96AV8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 2μM R03 exp134	-1.88
Metformin 100 to 150μM on day4 R04 exp170	1.76
Rapamycin 2μM R07 exp306	1.88
Aminopterin 0.005μM R07 exp335	2.34
Methotrexate 0.01μM R08 exp501	2.48

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15535
Expression level (log2 read counts): 5.61

Expression Distribution

positive regulation of DNA endoreduplication
negative regulation of transcription involved in G1/S transition of mitotic cell cycle
chorionic trophoblast cell differentiation
chorion development
negative regulation of cytokinesis
extraembryonic membrane development
regulation of DNA endoreduplication
positive regulation of DNA-dependent DNA replication
trophoblast giant cell differentiation
hepatocyte differentiation
negative regulation of cell division
cell differentiation involved in embryonic placenta development
regulation of transcription involved in G1/S transition of mitotic cell cycle
proximal promoter sequence-specific DNA binding
positive regulation of DNA replication
regulation of DNA-dependent DNA replication
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction involved in mitotic G1 DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic DNA damage checkpoint
intracellular signal transduction involved in G1 DNA damage checkpoint
signal transduction involved in mitotic DNA integrity checkpoint
sprouting angiogenesis
mitotic G1 DNA damage checkpoint
mitotic G1/S transition checkpoint
G1 DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
signal transduction involved in DNA damage checkpoint
RNA polymerase II transcription factor complex
signal transduction involved in cell cycle checkpoint
DNA damage response, signal transduction by p53 class mediator
positive regulation of cell cycle arrest
embryonic placenta development
regulation of cytokinesis
mitotic DNA damage checkpoint
negative regulation of G1/S transition of mitotic cell cycle
mitotic DNA integrity checkpoint
signal transduction in response to DNA damage
negative regulation of cell cycle G1/S phase transition
regulation of cell cycle arrest