E4F1

Entrez Summary: N/A
UniProt Summary: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.73
Dinaciclib 0.007μM R07 exp355	1.8
Tubacin 1.6μM R07 exp416	1.88
5-Azacytidine 2μM R07 exp330	2.19
VER-155008 3.9μM R06 exp301	2.27

Global Fraction of Cell Lines Where Essential: 24/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	2/25
breast	3/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	2/21
liver	1/20
lung	3/75
lymphocyte	0/14
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	1/24
soft tissue	2/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

regulation of mitotic cell cycle, embryonic
cAMP response element binding
mitotic cell cycle arrest
transferase activity
spindle
regulation of embryonic development
cell cycle arrest
DNA replication
transcription corepressor activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
transcription coactivator activity
negative regulation of mitotic cell cycle
RNA polymerase II regulatory region sequence-specific DNA binding
cell division
negative regulation of cell cycle
regulation of mitotic cell cycle
regulation of growth
DNA-binding transcription factor activity
protein ubiquitination
viral process
regulation of cell cycle process
protein modification by small protein conjugation
symbiotic process
interspecies interaction between organisms
negative regulation of transcription by RNA polymerase II
protein modification by small protein conjugation or removal
cell cycle process
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
cell cycle
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific