EAF2

Gene Information

Official Symbol: EAF2
Official Name: ELL associated factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 55840
UniProt: Q96CJ1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. {ECO:0000250, ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12907652, ECO:0000269|PubMed:16006523}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16098
Expression level (log2 read counts): 2.33

Expression Distribution

ELL-EAF complex
negative regulation of epithelial cell proliferation involved in prostate gland development
regulation of epithelial cell proliferation involved in prostate gland development
transcription elongation factor complex
negative regulation of reproductive process
transcription elongation from RNA polymerase II promoter
DNA-templated transcription, elongation
negative regulation of epithelial cell proliferation
regulation of reproductive process
negative regulation of cell growth
negative regulation of growth
RNA polymerase II regulatory region sequence-specific DNA binding
regulation of epithelial cell proliferation
nuclear speck
regulation of cell growth
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of growth
negative regulation of cell population proliferation
apoptotic process
negative regulation of developmental process
programmed cell death
cell death
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
regulation of cell population proliferation
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process