EFCAB4B

Gene Information

Official Symbol: CRACR2A
Official Name: calcium release activated channel regulator 2A
Aliases and Previous Symbols: N/A
Entrez ID: 84766
UniProt: Q9BSW2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12335
Expression level (log2 read counts): 5.58

Expression Distribution

Screen	Score
FK-506 5μM R07 exp358	1.77
MS023 2μM R03 exp134	1.83
Metformin 40μM R03 exp132	1.89

Miro
Arf
Ras
efhand

activation of store-operated calcium channel activity
positive regulation of store-operated calcium channel activity
store-operated calcium entry
regulation of store-operated calcium channel activity
positive regulation of calcium ion transmembrane transporter activity
specific granule lumen
positive regulation of cation channel activity
positive regulation of calcium ion transmembrane transport
regulation of calcium ion transmembrane transporter activity
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
positive regulation of calcium ion transport
positive regulation of cation transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
regulation of cation channel activity
positive regulation of transmembrane transport
regulation of calcium ion transport
calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
divalent metal ion transport
divalent inorganic cation transport
regulation of cation transmembrane transport
regulation of metal ion transport
regulation of ion transmembrane transport
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
regulation of transmembrane transport
myeloid leukocyte activation
adaptive immune response
leukocyte activation involved in immune response