EFS

Entrez Summary: N/A
UniProt Summary: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
GSK626616 14μM R08 exp485	-1.83
All-trans-Retinoic-Acid 40μM R07 exp334	-1.73

actin filament reorganization
actin cytoskeleton reorganization
SH3 domain binding
actin filament organization
protein domain specific binding
supramolecular fiber organization
actin cytoskeleton organization
actin filament-based process
cell adhesion
biological adhesion
cell migration
cell motility
localization of cell
cytoskeleton organization
locomotion
movement of cell or subcellular component
intracellular signal transduction