EIF3C

Entrez Summary: N/A
UniProt Summary: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.79
BI-6727 0.001μM R01 exp42	1.92

eIF-3c N
PCI

positive regulation of mRNA binding
positive regulation of RNA binding
regulation of mRNA binding
regulation of RNA binding
eukaryotic 48S preinitiation complex
eukaryotic translation initiation factor 3 complex
formation of cytoplasmic translation initiation complex
eukaryotic 43S preinitiation complex
translation initiation factor binding
cytoplasmic translational initiation
translation initiation factor activity
cytoplasmic translation
positive regulation of translation
translational initiation
positive regulation of cellular amide metabolic process
positive regulation of binding
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
regulation of translation
regulation of binding
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
ribonucleoprotein complex biogenesis
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
cellular protein-containing complex assembly
RNA binding
organonitrogen compound biosynthetic process
protein-containing complex assembly
positive regulation of cellular protein metabolic process
cellular nitrogen compound biosynthetic process
positive regulation of protein metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of molecular function
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process