EMX2

Entrez Summary: This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009].
UniProt Summary: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ureter morphogenesis
cerebral cortex regionalization
telencephalon regionalization
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
ureter development
dentate gyrus development
forebrain regionalization
cell proliferation in forebrain
forebrain cell migration
neural precursor cell proliferation
hippocampus development
limbic system development
cerebral cortex development
pallium development
anterior/posterior pattern specification
DNA-binding transcription repressor activity, RNA polymerase II-specific
telencephalon development
renal system development
urogenital system development
regionalization
forebrain development
sequence-specific DNA binding
pattern specification process
RNA polymerase II proximal promoter sequence-specific DNA binding
cell population proliferation
tube morphogenesis
brain development
head development
tube development
animal organ morphogenesis
cell migration
central nervous system development
neuron differentiation
response to drug
cell motility
localization of cell
locomotion
generation of neurons
movement of cell or subcellular component
DNA-binding transcription factor activity, RNA polymerase II-specific