EN2

Entrez Summary: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Engrail 1 C sig
Homeobox

RSC-type complex
embryonic brain development
midbrain development
fibrillar center
negative regulation of neuron apoptotic process
hindbrain development
negative regulation of neuron death
regulation of neuron apoptotic process
regulation of neuron death
sequence-specific DNA binding
embryonic organ development
brain development
head development
neuron development
nucleolus
negative regulation of apoptotic process
negative regulation of programmed cell death
embryo development
central nervous system development
negative regulation of cell death
neuron differentiation
positive regulation of transcription by RNA polymerase II
generation of neurons
regulation of apoptotic process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cell development
regulation of cell death
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
membrane
positive regulation of biosynthetic process