ENAH

Entrez Summary: This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016].
UniProt Summary: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lenalidomide 20μM R07 exp375	-1.81
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.79
Brefeldin A 0.02μM R00 exp8	1.81
Wortmannin 0.5μM R00 exp37	1.83

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

actin polymerization-dependent cell motility
profilin binding
WW domain binding
actin polymerization or depolymerization
filopodium
SH3 domain binding
lamellipodium
actin filament organization
axon guidance
neuron projection guidance
synapse
actin binding
cytoskeleton
axonogenesis
axon development
focal adhesion
cell morphogenesis involved in neuron differentiation
supramolecular fiber organization
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
actin cytoskeleton organization
cell part morphogenesis
cell junction
chemotaxis
taxis
cell morphogenesis involved in differentiation
actin filament-based process
neuron projection development
cell morphogenesis
neuron development
cellular component morphogenesis
neuron differentiation
cell motility
localization of cell
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
locomotion
generation of neurons