EPB41L3

Entrez Summary: N/A
UniProt Summary: Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 7μM R03 exp135	-2.17
L-BMAA 500 to 750μM on day4 R04 exp185	1.7
OICR-9429 10μM R03 exp142	1.7
PFI-2 4μM R05 exp239	1.89
Dimethyloxaloylglycine 100μM R05 exp229	2.01

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein localization to paranode region of axon
protein localization to juxtaparanode region of axon
paranodal junction assembly
protein localization to axon
cytoskeletal anchoring at plasma membrane
juxtaparanode region of axon
paranode region of axon
myelin maintenance
axolemma
myelin assembly
cortical actin cytoskeleton organization
cortical cytoskeleton organization
maintenance of protein location in cell
plasma membrane organization
maintenance of location in cell
structural constituent of cytoskeleton
cellular component assembly involved in morphogenesis
cell-cell junction assembly
myelination
maintenance of protein location
axon ensheathment
ensheathment of neurons
actomyosin structure organization
cell-cell junction organization
regulation of cell shape
maintenance of location
cell junction assembly
cell-cell junction
protein localization to plasma membrane
cell junction organization
protein localization to cell periphery
postsynaptic density
actin binding
cytoskeleton
regulation of cell growth
endomembrane system organization
neuron projection morphogenesis
protein localization to membrane
plasma membrane bounded cell projection morphogenesis
regulation of cell morphogenesis