EPN2

Entrez Summary: N/A
UniProt Summary: Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Staurosporine 0.02μM R08 exp524	1.83
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.98

ENTH
ANTH

clathrin coat of endocytic vesicle
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of sprouting angiogenesis
regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of Notch signaling pathway
regulation of sprouting angiogenesis
regulation of Notch signaling pathway
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
negative regulation of cellular response to growth factor stimulus
lipid binding
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
cadherin binding
regulation of vasculature development
endocytosis
import into cell
intracellular membrane-bounded organelle
membrane organization
negative regulation of developmental process
regulation of anatomical structure morphogenesis
negative regulation of multicellular organismal process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
vesicle-mediated transport