ERC2

Entrez Summary: N/A
UniProt Summary: Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

structural constituent of presynaptic active zone
maintenance of presynaptic active zone structure
presynaptic active zone organization
presynaptic active zone cytoplasmic component
maintenance of synapse structure
synaptic vesicle priming
presynaptic active zone
cellular component maintenance
synaptic vesicle exocytosis
GABA-ergic synapse
exocytic process
presynaptic membrane
neurotransmitter secretion
signal release from synapse
synaptic vesicle cycle
growth cone
vesicle-mediated transport in synapse
signal release
neurotransmitter transport
synapse organization
glutamatergic synapse
regulation of neurotransmitter levels
cytoskeleton
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
synaptic signaling
cell junction
regulated exocytosis
exocytosis
cellular protein-containing complex assembly
secretion by cell
export from cell
cell-cell signaling
secretion
protein-containing complex assembly
establishment of localization in cell
protein-containing complex subunit organization
vesicle-mediated transport