ERN2
Gene Information
- Official Symbol: ERN2
- Official Name: endoplasmic reticulum to nucleus signaling 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10595
- UniProt: Q76MJ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}.
Pfam Domains GO Terms
Pfam Domains
| Ribonuc 2-5A |
| Pkinase Tyr |
| Pkinase |
GO Terms
| IRE1-TRAF2-ASK1 complex |
| apoptotic chromosome condensation |
| rRNA catabolic process |
| apoptotic nuclear changes |
| endoribonuclease activity |
| cellular component disassembly involved in execution phase of apoptosis |
| ncRNA catabolic process |
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| endonuclease activity |
| activation of JUN kinase activity |
| chromosome condensation |
| execution phase of apoptosis |
| IRE1-mediated unfolded protein response |
| positive regulation of JUN kinase activity |
| RNA phosphodiester bond hydrolysis, endonucleolytic |
| JNK cascade |
| regulation of JUN kinase activity |
| stress-activated MAPK cascade |
| endoplasmic reticulum unfolded protein response |
| cellular response to unfolded protein |
| unfolded protein binding |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| cell cycle arrest |
| intrinsic apoptotic signaling pathway |
| cellular response to topologically incorrect protein |
| activation of MAPK activity |
| RNA phosphodiester bond hydrolysis |
| response to unfolded protein |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| DNA packaging |
| regulation of JNK cascade |
| response to topologically incorrect protein |
| magnesium ion binding |
| rRNA metabolic process |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| RNA catabolic process |
| response to endoplasmic reticulum stress |
| positive regulation of MAP kinase activity |
| apoptotic signaling pathway |
| DNA conformation change |
| nucleic acid phosphodiester bond hydrolysis |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| protein serine/threonine kinase activity |
| MAPK cascade |
| nucleobase-containing compound catabolic process |
| signal transduction by protein phosphorylation |
| cellular component disassembly |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ncRNA metabolic process |
| mRNA processing |
| organic cyclic compound catabolic process |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| mRNA metabolic process |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| RNA processing |
| cellular macromolecule catabolic process |
| apoptotic process |
| endoplasmic reticulum membrane |
| protein phosphorylation |
| regulation of transferase activity |
| cell cycle process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| macromolecule catabolic process |
| programmed cell death |
| positive regulation of phosphorylation |
| chromosome organization |
| cell death |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CR131-b 0.005μM R08 exp474 | -1.94 |
| Curcumin 6.5μM R06 exp277 | -1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3483
- Expression level (log2 read counts): 2.17
Expression Distribution
ERN2 Expression in NALM6 Cells: 2.17
