ETS2

Gene Information

Official Symbol: ETS2
Official Name: ETS proto-oncogene 2, transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 2114
UniProt: P15036
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18461
Expression level (log2 read counts): 7.18

Expression Distribution

SAM PNT
Ets

ectodermal cell fate commitment
ectoderm formation
ectodermal cell differentiation
primitive streak formation
glucocorticoid receptor binding
ectoderm development
cell fate commitment involved in formation of primary germ layer
gastrulation with mouth forming second
anterior/posterior axis specification
axis specification
formation of primary germ layer
mesoderm development
gastrulation
anterior/posterior pattern specification
protein domain specific binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
cell fate commitment
regionalization
pattern specification process
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
embryonic morphogenesis
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
anatomical structure formation involved in morphogenesis
embryo development
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription