EVX1

Gene Information

Official Symbol: EVX1
Official Name: even-skipped homeobox 1
Aliases and Previous Symbols: N/A
Entrez ID: 2128
UniProt: P49640
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in the specification of neuronal cell types.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	1.9
HMS-I1 10μM R06 exp256	2.11
Vinblastine 0.015μM R05 exp208	2.18
Nocodazole 0.2μM R02 exp64	2.39
SB743921 0.001μM R05 exp244	2.74
Rotenone 2μM R00 exp33	2.86
Nocodazole 0.2μM R00 exp24	3.53

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14904
Expression level (log2 read counts): -4.01

Expression Distribution

regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
cell fate specification involved in pattern specification
ventral spinal cord interneuron specification
cell fate commitment involved in pattern specification
ventral spinal cord interneuron fate commitment
ventral spinal cord interneuron differentiation
regulation of transcription involved in cell fate commitment
spinal cord dorsal/ventral patterning
spinal cord patterning
neuron fate specification
ventral spinal cord development
cell differentiation in spinal cord
neuron fate commitment
dorsal/ventral pattern formation
cell fate specification
spinal cord development
central nervous system neuron differentiation
cell fate commitment
regionalization
sequence-specific DNA binding
pattern specification process
embryo development ending in birth or egg hatching
DNA-binding transcription factor activity
embryo development
central nervous system development
neuron differentiation
positive regulation of transcription by RNA polymerase II
generation of neurons
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process