EXT2

Entrez Summary: This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:22660413}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glyco transf 64
Exostosin

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
UDP-N-acetylglucosamine transferase complex
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
heparan sulfate N-acetylglucosaminyltransferase activity
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
transferase activity, transferring glycosyl groups
acetylglucosaminyltransferase activity
glucuronosyltransferase activity
heparan sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
cellular polysaccharide biosynthetic process
polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
mesoderm formation
proteoglycan biosynthetic process
mesoderm morphogenesis
cellular polysaccharide metabolic process
polysaccharide metabolic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
formation of primary germ layer
mesoderm development
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
gastrulation
aminoglycan metabolic process
cellular carbohydrate metabolic process
protein glycosylation
macromolecule glycosylation
ossification
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
protein heterodimerization activity
tissue morphogenesis
embryonic morphogenesis
carbohydrate derivative biosynthetic process
Golgi membrane