EZR
Gene Information
- Official Symbol: EZR
- Official Name: ezrin
- Aliases and Previous Symbols: N/A
- Entrez ID: 7430
- UniProt: P15311
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.
Pfam Domains GO Terms
Pfam Domains
| FERM C |
| ERM |
| FERM N |
| FERM M |
GO Terms
| intestinal D-glucose absorption |
| Schwann cell microvillus |
| cytoplasmic side of apical plasma membrane |
| terminal web assembly |
| negative regulation of interleukin-2 secretion |
| protein localization to cell cortex |
| microspike |
| cell tip |
| cortical microtubule organization |
| membrane to membrane docking |
| intestinal hexose absorption |
| negative regulation of p38MAPK cascade |
| astrocyte projection |
| regulation of interleukin-2 secretion |
| regulation of microvillus length |
| astral microtubule organization |
| positive regulation of early endosome to late endosome transport |
| regulation of protein localization to early endosome |
| positive regulation of protein localization to early endosome |
| establishment of centrosome localization |
| invadopodium |
| cytoskeletal anchoring at plasma membrane |
| sphingosine-1-phosphate receptor signaling pathway |
| positive regulation of protein localization to endosome |
| sphingolipid mediated signaling pathway |
| uropod |
| regulation of protein localization to endosome |
| positive regulation of cytoplasmic transport |
| regulation of microvillus organization |
| protein kinase A catalytic subunit binding |
| protein kinase A signaling |
| regulation of cell projection size |
| S100 protein binding |
| establishment of epithelial cell apical/basal polarity |
| regulation of early endosome to late endosome transport |
| microvillus assembly |
| filopodium assembly |
| cortical cytoskeleton |
| microvillus organization |
| polarized epithelial cell differentiation |
| negative regulation of T cell receptor signaling pathway |
| establishment of apical/basal cell polarity |
| protein kinase A regulatory subunit binding |
| establishment of monopolar cell polarity |
| negative regulation of interleukin-2 production |
| microvillus membrane |
| establishment or maintenance of monopolar cell polarity |
| cellular protein-containing complex localization |
| regulation of cytoplasmic transport |
| protein kinase A binding |
| negative regulation of antigen receptor-mediated signaling pathway |
| centrosome localization |
| microtubule organizing center localization |
| plasma membrane raft |
| establishment of epithelial cell polarity |
| positive regulation of multicellular organism growth |
| establishment of endothelial barrier |
| intestinal absorption |
| disordered domain specific binding |
| immunological synapse |
| cell periphery |
| regulation of T cell receptor signaling pathway |
| regulation of p38MAPK cascade |
| cortical actin cytoskeleton organization |
| T-tubule |
| morphogenesis of a polarized epithelium |
| negative regulation of stress-activated protein kinase signaling cascade |
| negative regulation of stress-activated MAPK cascade |
| establishment or maintenance of epithelial cell apical/basal polarity |
| cortical cytoskeleton organization |
| establishment or maintenance of bipolar cell polarity |
| establishment or maintenance of apical/basal cell polarity |
| leukocyte cell-cell adhesion |
| endothelial cell development |
| brush border |
| cytoplasmic microtubule organization |
| regulation of interleukin-2 production |
| cellular response to cAMP |
| positive regulation of protein localization to plasma membrane |
| cell adhesion molecule binding |
| receptor internalization |
| positive regulation of protein localization to cell periphery |
| regulation of antigen receptor-mediated signaling pathway |
| microvillus |
| actin filament bundle assembly |
| extrinsic component of membrane |
| actin cytoskeleton reorganization |
| regulation of multicellular organism growth |
| actin filament bundle organization |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of cytokine secretion |
| apical part of cell |
| phosphatidylinositol-mediated signaling |
| cell body |
| filopodium |
| digestive system process |
| inositol lipid-mediated signaling |
| maintenance of protein location in cell |
| carbohydrate transport |
| ATPase binding |
| actin filament |
| endothelial cell differentiation |
| ruffle |
| regulation of protein localization to plasma membrane |
| maintenance of location in cell |
| endothelium development |
| ruffle membrane |
| cell projection |
| response to cAMP |
| gland morphogenesis |
| receptor metabolic process |
| maintenance of protein location |
| regulation of NIK/NF-kappaB signaling |
| digestion |
| regulation of protein localization to cell periphery |
| establishment of cell polarity |
| positive regulation of protein localization to membrane |
| negative regulation of protein secretion |
| fibrillar center |
| response to organophosphorus |
| ciliary basal body |
| negative regulation of peptide secretion |
| positive regulation of cellular protein catabolic process |
| vesicle |
| regulation of cell shape |
| response to purine-containing compound |
| spindle organization |
| maintenance of location |
| negative regulation of MAPK cascade |
| positive regulation of developmental growth |
| membrane docking |
| negative regulation of protein transport |
| regulation of cell size |
| protein localization to plasma membrane |
| negative regulation of establishment of protein localization |
| protein C-terminus binding |
| regulation of protein localization to membrane |
| epithelial cell development |
| establishment or maintenance of cell polarity |
| basolateral plasma membrane |
| actin filament binding |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| positive regulation of intracellular transport |
| actin cytoskeleton |
| positive regulation of protein catabolic process |
| regulation of organelle assembly |
| protein localization to cell periphery |
| negative regulation of secretion |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| receptor-mediated endocytosis |
| microtubule binding |
| actin filament organization |
| protein domain specific binding |
| regulation of cellular protein catabolic process |
| protein-containing complex localization |
| positive regulation of growth |
| axon guidance |
| neuron projection guidance |
| actin binding |
| endosome |
| positive regulation of protein secretion |
| negative regulation of cytokine production |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| cadherin binding |
| apical plasma membrane |
| positive regulation of cellular protein localization |
| regulation of developmental growth |
| regulation of actin cytoskeleton organization |
| regulation of intracellular transport |
| establishment of organelle localization |
| positive regulation of cellular catabolic process |
| axonogenesis |
| regulation of cellular component size |
| regulation of protein catabolic process |
| regulation of actin filament-based process |
| positive regulation of secretion by cell |
| negative regulation of protein phosphorylation |
| axon development |
| gland development |
| focal adhesion |
| positive regulation of protein transport |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| positive regulation of catabolic process |
| positive regulation of secretion |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| plasma membrane bounded cell projection assembly |
| supramolecular fiber organization |
| cell projection assembly |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| microtubule cytoskeleton organization |
| protein localization to membrane |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| negative regulation of transport |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| regulation of peptide secretion |
| cell-cell adhesion |
| negative regulation of intracellular signal transduction |
| cell part morphogenesis |
| regulation of anatomical structure size |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| cellular response to organic cyclic compound |
| chemotaxis |
| regulation of vesicle-mediated transport |
| taxis |
| endocytosis |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| actin filament-based process |
| organelle localization |
| negative regulation of protein modification process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| cellular response to nitrogen compound |
| neuron projection development |
| microtubule-based process |
| regulation of growth |
| import into cell |
| epithelial cell differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| regulation of cell projection organization |
| cell morphogenesis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| organelle assembly |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| negative regulation of transcription by RNA polymerase II |
| regulation of cellular localization |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| positive regulation of transport |
| regulation of catabolic process |
| cell cycle process |
| response to organonitrogen compound |
| neuron differentiation |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| epithelium development |
| plasma membrane bounded cell projection organization |
| regulation of immune response |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of organelle organization |
| locomotion |
| G protein-coupled receptor signaling pathway |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| vesicle-mediated transport |
| system process |
| positive regulation of gene expression |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Deferoxamine 11μM R07 exp350 | -1.98 |
| THZ1 0.06μM R08 exp531 | -1.74 |
| Pimelic-diphenylamide-106 0.5μM R00 exp27 | 1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3841
- Expression level (log2 read counts): 7.82
Expression Distribution
EZR Expression in NALM6 Cells: 7.82
