F2
Gene Information
- Official Symbol: F2
- Official Name: coagulation factor II, thrombin
- Aliases and Previous Symbols: N/A
- Entrez ID: 2147
- UniProt: P00734
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Trypsin |
| Thrombin light |
| Gla |
| Kringle |
GO Terms
| cytolysis by host of symbiont cells |
| cytolysis in other organism involved in symbiotic interaction |
| neutrophil mediated killing of gram-negative bacterium |
| thrombospondin receptor activity |
| positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| neutrophil mediated killing of bacterium |
| neutrophil mediated killing of symbiont cell |
| cytolysis in other organism |
| neutrophil mediated cytotoxicity |
| regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| killing by host of symbiont cells |
| disruption by host of symbiont cells |
| negative regulation of fibrinolysis |
| negative regulation of astrocyte differentiation |
| killing of cells in other organism involved in symbiotic interaction |
| disruption of cells of other organism involved in symbiotic interaction |
| regulation of fibrinolysis |
| negative regulation of cytokine production involved in inflammatory response |
| blood coagulation, intrinsic pathway |
| negative regulation of platelet activation |
| fibrinolysis |
| multi-organism cellular process |
| cytolysis |
| positive regulation of collagen biosynthetic process |
| negative regulation of glial cell differentiation |
| blood coagulation, fibrin clot formation |
| positive regulation of collagen metabolic process |
| positive regulation of hemostasis |
| protein activation cascade |
| positive regulation of blood coagulation |
| positive regulation of coagulation |
| regulation of astrocyte differentiation |
| positive regulation of G protein-coupled receptor signaling pathway |
| regulation of platelet activation |
| lipopolysaccharide binding |
| regulation of collagen biosynthetic process |
| positive regulation of lipid kinase activity |
| acute-phase response |
| regulation of cytokine production involved in inflammatory response |
| regulation of collagen metabolic process |
| positive regulation of release of sequestered calcium ion into cytosol |
| negative regulation of gliogenesis |
| leukocyte mediated cytotoxicity |
| enzyme activator activity |
| killing of cells of other organism |
| disruption of cells of other organism |
| negative regulation of blood coagulation |
| negative regulation of hemostasis |
| negative regulation of coagulation |
| positive regulation of calcium ion transport into cytosol |
| positive regulation of wound healing |
| regulation of lipid kinase activity |
| positive regulation of response to wounding |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| regulation of glial cell differentiation |
| positive regulation of calcium ion transmembrane transport |
| acute inflammatory response |
| modification by host of symbiont morphology or physiology |
| negative regulation of wound healing |
| positive regulation of protein localization to nucleus |
| interaction with symbiont |
| regulation of release of sequestered calcium ion into cytosol |
| regulation of blood coagulation |
| regulation of hemostasis |
| regulation of coagulation |
| defense response to Gram-negative bacterium |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| negative regulation of response to wounding |
| positive regulation of receptor signaling pathway via STAT |
| cell killing |
| positive regulation of reactive oxygen species metabolic process |
| regulation of calcium ion transport into cytosol |
| Golgi lumen |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| antimicrobial humoral response |
| regulation of gliogenesis |
| regulation of protein localization to nucleus |
| regulation of complement activation |
| regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| regulation of humoral immune response |
| negative regulation of inflammatory response |
| platelet activation |
| regulation of wound healing |
| positive regulation of lipid metabolic process |
| blood microparticle |
| positive regulation of cation transmembrane transport |
| regulation of G protein-coupled receptor signaling pathway |
| regulation of calcium ion transmembrane transport |
| regulation of cell shape |
| positive regulation of ion transmembrane transport |
| modification of morphology or physiology of other organism |
| growth factor activity |
| positive regulation of cell growth |
| serine-type endopeptidase activity |
| regulation of response to wounding |
| heparin binding |
| regulation of reactive oxygen species metabolic process |
| negative regulation of cell activation |
| positive regulation of transmembrane transport |
| negative regulation of defense response |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| regulation of calcium ion transport |
| positive regulation of growth |
| negative regulation of cytokine production |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| negative regulation of neurogenesis |
| blood coagulation |
| coagulation |
| hemostasis |
| endoplasmic reticulum lumen |
| negative regulation of nervous system development |
| positive regulation of cellular protein localization |
| regulation of cytosolic calcium ion concentration |
| defense response to bacterium |
| negative regulation of cell development |
| regulation of cation transmembrane transport |
| signaling receptor binding |
| regulation of inflammatory response |
| humoral immune response |
| negative regulation of proteolysis |
| collagen-containing extracellular matrix |
| negative regulation of response to external stimulus |
| Golgi vesicle transport |
| leukocyte migration |
| regulation of metal ion transport |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| regulation of cell growth |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of immune effector process |
| regulation of ion transmembrane transport |
| wound healing |
| regulation of cell morphogenesis |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| inflammatory response |
| neutrophil mediated immunity |
| myeloid leukocyte mediated immunity |
| regulation of cellular protein localization |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| response to wounding |
| positive regulation of kinase activity |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| regulation of growth |
| response to bacterium |
| regulation of cytokine production |
| regulation of ion transport |
| cation homeostasis |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of proteolysis |
| cellular chemical homeostasis |
| regulation of defense response |
| leukocyte mediated immunity |
| symbiotic process |
| ion homeostasis |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| regulation of kinase activity |
| cellular homeostasis |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| defense response to other organism |
| cell migration |
| regulation of transferase activity |
| positive regulation of transport |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| intracellular transport |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MK2206 4μM R08 exp504 | -2.01 |
| proTAME 5μM R04 exp187 | 1.7 |
| Ribavirin 10μM R01 exp52 | 1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4606
- Expression level (log2 read counts): -1.6
Expression Distribution
F2 Expression in NALM6 Cells: -1.6
