F2RL2

Entrez Summary: N/A
UniProt Summary: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. {ECO:0000269|PubMed:10079109}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.95
Bisphenol F 50μM R08 exp457	1.73

thrombin-activated receptor activity
thrombin-activated receptor signaling pathway
phosphatidylinositol phospholipase C activity
positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
phospholipase C-activating G protein-coupled receptor signaling pathway
platelet activation
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
positive regulation of cytosolic calcium ion concentration
blood coagulation
coagulation
hemostasis
apical plasma membrane
regulation of cytosolic calcium ion concentration
regulation of small GTPase mediated signal transduction
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
wound healing
divalent inorganic cation homeostasis
regulation of body fluid levels
cellular metal ion homeostasis
response to wounding
protein-containing complex
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
positive regulation of intracellular signal transduction
cell activation
chemical homeostasis
G protein-coupled receptor signaling pathway