FAIM

Entrez Summary: The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
UniProt Summary: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors
I-kappaB kinase/NF-kappaB signaling
negative regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway
negative regulation of apoptotic signaling pathway
regulation of apoptotic signaling pathway
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
regulation of neurogenesis
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
negative regulation of cell death
programmed cell death
cell death
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of developmental process
generation of neurons
regulation of apoptotic process
regulation of programmed cell death
negative regulation of response to stimulus
neurogenesis
regulation of cell death
intracellular signal transduction
positive regulation of multicellular organismal process
regulation of cell differentiation