FAM170B

Entrez Summary: N/A
UniProt Summary: Plays a role in fertilization through the acrosome reaction. {ECO:0000250|UniProtKB:E9PXT9}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UNC1999 2μM R03 exp155	-1.74
Deguelin 0.05μM R02 exp69	1.89

outer acrosomal membrane
positive regulation of acrosome reaction
positive regulation of fertilization
regulation of acrosome reaction
regulation of fertilization
positive regulation of reproductive process
acrosomal vesicle
regulation of reproductive process
positive regulation of multi-organism process
regulation of multi-organism process