FAM175B

Gene Information

Official Symbol: ABRAXAS2
Official Name: abraxas 2, BRISC complex subunit
Aliases and Previous Symbols: N/A
Entrez ID: 23172
UniProt: Q15018
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys- 63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-3.02
LY2090314 0.003μM R08 exp500 no dilution day6	-2.29
GSK-J4 1-1.25μM to day4 R07 exp363	1.71
Talazoparib 0.006μM R06 exp299	1.75
DKK1 89ng/ml R08 exp477	1.82
Calcium Ionophore 0.4μM R07 exp342	1.96
5-Fluorouracil 20μM R00 exp2	1.97

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17944
Expression level (log2 read counts): 5.05

Expression Distribution

BRISC complex
microtubule minus-end
spindle pole centrosome
attachment of spindle microtubules to kinetochore
polyubiquitin modification-dependent protein binding
protein K63-linked deubiquitination
mitotic spindle assembly
response to ischemia
mitotic spindle organization
spindle assembly
microtubule cytoskeleton organization involved in mitosis
mitotic nuclear division
spindle organization
midbody
nuclear chromosome segregation
microtubule binding
chromosome segregation
protein deubiquitination
nuclear division
protein modification by small protein removal
organelle fission
microtubule cytoskeleton organization
centrosome
cell division
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
organelle assembly
protein modification by small protein conjugation or removal
cell cycle process
cytoskeleton organization
proteolysis
cell cycle