FAR2

Entrez Summary: N/A
UniProt Summary: Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). {ECO:0000250|UniProtKB:Q8WVX9, ECO:0000269|PubMed:15220348}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

alcohol-forming fatty acyl-CoA reductase activity
fatty-acyl-CoA reductase (alcohol-forming) activity
wax biosynthetic process
wax metabolic process
integral component of peroxisomal membrane
long-chain fatty-acyl-CoA metabolic process
fatty-acyl-CoA metabolic process
peroxisomal matrix
fatty acid derivative biosynthetic process
thioester metabolic process
acyl-CoA metabolic process
peroxisome
oxidoreductase activity
ribonucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
fatty acid derivative metabolic process
coenzyme metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
nucleobase-containing small molecule metabolic process
cellular amide metabolic process
organophosphate metabolic process
oxidation-reduction process
carbohydrate derivative metabolic process
lipid metabolic process
small molecule metabolic process