FASLG

Gene Information

Official Symbol: FASLG
Official Name: Fas ligand
Aliases and Previous Symbols: N/A
Entrez ID: 356
UniProt: P48023
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014].
UniProt Summary: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260). {ECO:0000250|UniProtKB:P41047, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:27806260, ECO:0000269|PubMed:7528780, ECO:0000269|PubMed:9228058, ECO:0000269|PubMed:9427603}. FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. {ECO:0000269|PubMed:17557115}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7196
Expression level (log2 read counts): -0.64

Expression Distribution

retinal cell programmed cell death
endosomal lumen acidification
cellular chloride ion homeostasis
cytoplasmic vesicle lumen
necroptotic signaling pathway
inflammatory cell apoptotic process
release of sequestered calcium ion into cytosol by endoplasmic reticulum
programmed cell death involved in cell development
cellular monovalent inorganic anion homeostasis
cellular anion homeostasis
T cell apoptotic process
chloride ion homeostasis
death receptor binding
lymphocyte apoptotic process
positive regulation of endothelial cell apoptotic process
necroptotic process
leukocyte apoptotic process
monovalent inorganic anion homeostasis
programmed necrotic cell death
necrotic cell death
tumor necrosis factor receptor binding
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of epithelial cell apoptotic process
positive regulation of ERBB signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
intracellular pH reduction
pH reduction
regulation of endothelial cell apoptotic process
positive regulation of neuron apoptotic process
release of sequestered calcium ion into cytosol
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of sequestering of calcium ion
anion homeostasis
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
caveola
endosome organization
regulation of epithelial cell apoptotic process
regulation of epidermal growth factor receptor signaling pathway