FBLN1

Entrez Summary: Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

EGF CA
cEGF

elastic fiber
fibrinogen binding
peptidase activator activity
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of stem cell proliferation
blood coagulation, fibrin clot formation
protein activation cascade
fibronectin binding
embryo implantation
regulation of substrate adhesion-dependent cell spreading
negative regulation of cell-substrate adhesion
regulation of stem cell proliferation
negative regulation of ERK1 and ERK2 cascade
basement membrane
integrin-mediated signaling pathway
negative regulation of cell morphogenesis involved in differentiation
extracellular matrix structural constituent
negative regulation of MAPK cascade
female pregnancy
protein C-terminus binding
positive regulation of peptidase activity
multi-multicellular organism process
regulation of cell-substrate adhesion
extracellular matrix
protein-containing complex binding
negative regulation of cell adhesion
negative regulation of cell motility
regulation of ERK1 and ERK2 cascade
blood coagulation
coagulation
hemostasis
regulation of cell morphogenesis involved in differentiation
negative regulation of cellular component movement
negative regulation of locomotion
negative regulation of cell development
extracellular matrix organization
positive regulation of proteolysis
collagen-containing extracellular matrix
extracellular structure organization
negative regulation of protein phosphorylation